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Multi-target combinatory strategy to overcome tumor immune escape

《医学前沿（英文）》 2022年 第16卷 第2期   页码 208-215 doi: 10.1007/s11684-022-0922-5

摘要： Immune therapy has become the fourth approach after surgery, chemotherapy, and radiotherapy in cancer treatment. Many immune checkpoints were identified in the last decade since ipilimumab, which is the first immune checkpoint inhibitor to cytotoxic T-lymphocyte associated protein 4, had been approved by the US Food and Drug Administration (FDA) for the treatment of unresectable or metastatic melanoma in 2011. The use of several antibody drugs that target PD1/PD-L1 for various cancer treatments has been approved by the FDA. However, fewer people are benefitting from immune checkpoint inhibitor treatment in solid cancers. Approximately 80% of patients do not respond appropriately because of primary or acquired therapeutic resistance. Along with the characterization of more immune checkpoints, the combinatory treatment of multi-immune checkpoint inhibitors becomes a new option when monotherapy could not receive a good response. In this work, the author focuses on the combination therapy of multiple immune checkpoints (does not include targeted therapy of oncogenes or chemotherapy), introduces the current progression of multiple immune checkpoints and their related inhibitors, and discusses the advantages of combination therapy, as well as the risk of immune-related adverse events.

关键词： immune checkpoints     multi-target     immune escape     immune-related adverse events     combination therapy    

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Atypical pituitary hormone–target tissue axis

《医学前沿（英文）》 2023年 第17卷 第1期   页码 1-17 doi: 10.1007/s11684-022-0973-7

摘要： A long-held belief is that pituitary hormones bind to their cognate receptors in classical target glands to actuate their manifold functions. However, a number of studies have shown that multiple types of pituitary hormone receptors are widely expressed in non-classical target organs. Each pituitary gland-derived hormone exhibits a wide range of nonconventional biological effects in these non-classical target organs. Herein, the extra biological functions of pituitary hormones, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotrophic hormone, and prolactin when they act on non-classical organs were summarized, defined by the novel concept of an “atypical pituitary hormone–target tissue axis.” This novel proposal explains the pathomechanisms of abnormal glucose and lipid metabolism, obesity, hypertension, fatty liver, and atherosclerosis while offering a more comprehensive and systematic insights into the coordinated regulation of environmental factors, genetic factors, and neuroendocrine hormones on human biological functions. The continued exploration of the physiology of the “atypical pituitary hormone–target tissue axis” could enable the identification of novel therapeutic targets for metabolic diseases.

关键词： thyroid-stimulating hormone     follicle-stimulating hormone     luteinizing hormone     adrenocorticotrophic hormone     prolactin    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

null

《医学前沿（英文）》 2016年 第10卷 第1期   页码 52-60 doi: 10.1007/s11684-016-0433-3

摘要：

Hepatocellular carcinoma (HCC) is a lethal liver malignancy worldwide. In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressed in the majority of HCC cases (approximately 59%) and significantly associated with high serum α-fetoprotein (AFP) level (P= 0.044). Kaplan-Meier and Cox regression data indicated that PPM1D overexpression was an independent predictor of HCC-specific overall survival (HR, 2.799; 95% CI, 1.346–5.818, P = 0.006). Overexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdown of PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. In addition, PPM1D suppression by small interfering RNA decreased the tumorigenicity of HCC cells in vivo. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target for HCC.

关键词： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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Amodified variable rate particle filter for maneuvering target tracking

Yun-fei GUO,Kong-shuai FAN,Dong-liang PENG,Ji-an LUO,Han SHENTU

《信息与电子工程前沿（英文）》 2015年 第16卷 第11期   页码 985-994 doi: 10.1631/FITEE.1500149

摘要： To address the problem of maneuvering target tracking, where the target trajectory has prolonged smooth regions and abrupt maneuvering regions, a modified variable rate particle filter (MVRPF) is proposed. First, a Cartesian-coordinate based variable rate model is presented. Compared with conventional variable rate models, the proposed model does not need any prior knowledge of target mass or external forces. Consequently, it is more convenient in practical tracking applications. Second, a maneuvering detection strategy is adopted to adaptively adjust the parameters in MVRPF, which helps allocate more state points at high maneuver regions and fewer at smooth regions. Third, in the presence of small measurement errors, the unscented particle filter, which is embedded in MVRPF, can move more particles into regions of high likelihood and hence can improve the tracking performance. Simulation results illustrate the effectiveness of the proposed method.

关键词： Maneuvering target tracking     Prolonged smooth regions     Variable rate model     Maneuver detection    

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Lightweight design of an electric bus body structure with analytical target cascading

《机械工程前沿（英文）》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0718-y

摘要： Lightweight designs of new-energy vehicles can reduce energy consumption, thereby improving driving mileage. In this study, a lightweight design of a newly developed multi-material electric bus body structure is examined in combination with analytical target cascading (ATC). By proposing an ATC-based two-level optimization strategy, the original lightweight design problem is decomposed into the system level and three subsystem levels. The system-level optimization model is related to mass minimization with all the structural modal frequency constraints, while each subsystem-level optimization model is related to the sub-structural performance objective with sub-structure mass constraints. To enhance the interaction between two-level systems, each subsystem-level objective is reformulated as a penalty-based function coordinated with the system-level objective. To guarantee the accuracy of the model-based analysis, a finite element model is validated through experimental modal test. A sequential quadratic programming algorithm is used to address the defined optimization problem for effective convergence. Compared with the initial design, the total mass is reduced by 49 kg, and the torsional stiffness is increased by 17.5%. In addition, the obtained design is also validated through strength analysis.

关键词： electric vehicle     body in white (BIW)     lightweight     analytical target cascading (ATC)    

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Dynamic Target Tracking of Unmanned Aerial Vehicles Under Unpredictable Disturbances

Yanjie Chen,Yangning Wu,Limin Lan,Hang Zhong,Zhiqiang Miao,Hui Zhang,Yaonan Wang,

《工程（英文）》 doi: 10.1016/j.eng.2023.05.017

摘要： This study proposes an image-based visual servoing (IBVS) method based on a velocity observer for an unmanned aerial vehicle (UAV) for tracking a dynamic target in Global Positioning System (GPS)-denied environments. The proposed method derives the simplified and decoupled image dynamics of underactuated UAVs using a constructed virtual camera and then considers the uncertainties caused by the unpredictable rotations and velocities of the dynamic target. A novel image depth model that extends the IBVS method to track a rotating target with arbitrary orientations is proposed. The depth model ensures image feature accuracy and image trajectory smoothness in rotating target tracking. The relative velocities of the UAV and the dynamic target are estimated using the proposed velocity observer. Thanks to the velocity observer, translational velocity measurements are not required, and the control chatter caused by noise-containing measurements is mitigated. An integral-based filter is proposed to compensate for unpredictable environmental disturbances in order to improve the anti-disturbance ability. The stability of the velocity observer and IBVS controller is analyzed using the Lyapunov method. Comparative simulations and multistage experiments are conducted to illustrate the tracking stability, anti-disturbance ability, and tracking robustness of the proposed method with a dynamic rotating target.

关键词： Unmanned aerial vehicle     Visual servoing     Velocity observer     Target tracking    

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A methodology of implementing target mixing ratio for asphalt mixture

Yucheng HUANG, Lun JI, Rui WEN, Ming ZHANG

《结构与土木工程前沿（英文）》 2017年 第11卷 第3期   页码 308-314 doi: 10.1007/s11709-017-0405-y

摘要： In order to implement the objective mix design of hot mix asphalt adequately during the construction process, the significance of objective mixing ratio was elaborated, and the variability of materials and its control method were analyzed. An engineering example is used to illustrate the debugging process of asphalt mixture batching & mixing plant and the dynamic quality management methods. The results show that the set of methods can not only implement the objective mixing ratio of hot mix asphalt adequately, but also control production during the construction process effectively.

关键词： asphalt mixture     target mixing ratio     mix design implementation     batching & mixing plant debugging    

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应用基本遗传算法进行水面舰船目标识别研究

蒋定定,许兆林,李开端

《中国工程科学》 2004年 第6卷 第8期   页码 79-81

摘要：

水面舰船识别判读是海军航空侦察工作的重要内容。文章论述了基本遗传算法（SGA）的原理、特点和运算步骤，并将该算法引入对水面舰船的识别。实验结果证明了该方法的科学性和实用性。

关键词： 基本遗传算法     目标识别     水面舰船    

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Moving target detection in the cepstrum domain for passive coherent location (PCL) radar

Ji-chuan LI,Xiao-de LU,Hui ZHANG,Peng-cheng YANG,Yu LIU,Mao-sheng XIANG

《信息与电子工程前沿（英文）》 2015年 第16卷 第9期   页码 785-795 doi: 10.1631/FITEE.1500036

摘要： A cepstrum moving target detection (CEPMTD) algorithm based on cepstrum techniques is proposed for passive coherent location (PCL) radar systems. The primary cepstrum techniques are of great success in recognizing the arrival times of static target echoes. To estimate the Doppler frequencies of moving targets, we divide the radar data into a large number of segments, and reformat these segments into a detection matrix. Applying the cepstrum and the Fourier transform to the fast and slow time dimensions respectively, we can obtain the range information and Doppler information of the moving targets. Based on the CEPMTD outlined above, an improved CEPMTD algorithm is proposed to improve the detection performance. Theoretical analyses show that only the target’s peak can be coherently added. The performance of the improved CEPMTD is initially validated by simulations, and then by experiments. The simulation results show that the detection performance of the improved CEPMTD algorithm is 13.3 dB better than that of the CEPMTD algorithm and 6.4 dB better than that of the classical detection algorithm based on the radar cross ambiguity function (CAF). The experiment results show that the detection performance of the improved CEPMTD algorithm is 1.63 dB better than that of the radar CAF.

关键词： Moving target detection     Cepstrum techniques     Cross ambiguity function (CAF)     Passive coherent location (PCL) radar    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

《医学前沿（英文）》 2022年 第16卷 第4期   页码 627-636 doi: 10.1007/s11684-020-0815-4

摘要： Runt-related transcription factor 1 (RUNX1) is an essential regulator of normal hematopoiesis. Its dysfunction, caused by either fusions or mutations, is frequently reported in acute myeloid leukemia (AML). However, RUNX1 mutations have been largely under-explored compared with RUNX1 fusions mainly due to their elusive genetic characteristics. Here, based on 1741 patients with AML, we report a unique expression pattern associated with RUNX1 mutations in AML. This expression pattern was coordinated by target repression and promoter hypermethylation. We first reanalyzed a joint AML cohort that consisted of three public cohorts and found that RUNX1 mutations were mainly distributed in the Runt domain and almost mutually exclusive with NPM1 mutations. Then, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signature that significantly distinguished the patients with RUNX1 mutations from those with other AML subtypes. Furthermore, we explored the mechanisms underlying this signature from the transcriptional and epigenetic levels. Using chromatin immunoprecipitation sequencing data, we found that RUNX1 target genes tended to be repressed in patients with RUNX1 mutations. Through the integration of DNA methylation array data, we illustrated that hypermethylation on the promoter regions of RUNX1-regulated genes also contributed to dysregulation in RUNX1-mutated AML. This study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying mechanisms in AML development.

关键词： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Anovel approach of noise statistics estimate using H∞ filter in target tracking

Xie WANG,Mei-qin LIU,Zhen FAN,Sen-lin ZHANG

《信息与电子工程前沿（英文）》 2016年 第17卷 第5期   页码 449-457 doi: 10.1631/FITEE.1500262

摘要： Noise statistics are essential for estimation performance. In practical situations, however, a priori information of noise statistics is often imperfect. Previous work on noise statistics identification in linear systems still requires initial prior knowledge of the noise. A novel approach is presented in this paper to solve this paradox. First, we apply the H∞ filter to obtain the system state estimates without the common assumptions about the noise in conventional adaptive filters. Then by applying state estimates obtained from the H∞ filter, better estimates of the noise mean and covariance can be achieved, which can improve the performance of estimation. The proposed approach makes the best use of the system knowledge without a priori information with modest computation cost, which makes it possible to be applied online. Finally, numerical examples are presented to show the efficiency of this approach.

关键词： Noise estimate     H∞     filter     Target tracking    

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Speciation evolutions of target metals (Cd, Pb) influenced by chlorine and sulfur during sewage sludge

Jingde LUAN,Rundong LI,Zhihui ZHANG,Yanlong LI,Yun ZHAO

《环境科学与工程前沿（英文）》 2014年 第8卷 第6期   页码 871-876 doi: 10.1007/s11783-013-0621-1

摘要： In sludge incineration, the thermal behavior of heavy metal is a growing concern. In this work, the combined analysis of metal partitioning behavior between vapor phase and condensed phase, speciation redistribution in condensed phase and the difference of metal species in binding energy was carried out to investigate the possible volatilization-condensation mechanism of heavy metals in high-temperature sludge incineration. It was found that there were two steps in metal volatilization. The initial volatilization of heavy metal originated from their exchangeable (EXC), carbonate bound (CAR) and iron–manganese bound (FM) fractions, which is primarily composed of simple substance, chlorides, oxides and sulfides. With the increase of chlorine and sulfur in sludge, the inner speciation redistribution of heavy metals occurred in condensed phase, which was an important factor affecting the potential volatility of heavy metals. A partial of metal species with complexed (COM) and residual (RES) fractions gradually decomposed into simple substance or ions, oxides and carbonates, which significantly strengthened the second volatility. In presence of chlorine, about 46% of Cd with the RES fraction disappeared when the volatility rate of Cd increased by 44.89%. Moreover, about 9% of Pb with COM fraction disappeared when there was an increase of nearly 10% in the volatilization rate. Thus, the second volatilization was mainly controlled by the decomposition of metal species with COM and RES fractions. By virtue of XRD analysis and the binding energy calculation, it was found that metal complex and silicates were inclined to decompose under high temperature due to poor thermo stability as compared with sulfates.

关键词： sludge incineration     heavy metals     inner speciation redistribution     binding energy    

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support and metal oxide nanoparticles in hybrid nanosorbent materials (HNMs) for sorption/desorption of target

Ryan C. SMITH,Jinze LI,Surapol PADUNGTHON,Arup K. SENGUPTA

《环境科学与工程前沿（英文）》 2015年 第9卷 第5期   页码 929-938 doi: 10.1007/s11783-015-0795-9

摘要： Metal oxide nanoparticles like hydrated ferric oxide (HFO) or hydrated zirconium oxide (HZrO) are excellent sorbents for environmentally significant ligands like phosphate, arsenic, or fluoride, present at trace concentrations. Since the sorption capacity is surface dependent for HFO and HZrO, nanoscale sizes offer significant enhancement in performance. However, due to their miniscule sizes, low attrition resistance, and poor durability they are unable to be used in typical plug-flow column setups. Meanwhile ion exchange resins, which have no specific affinity toward anionic ligands, are durable and chemically stable. By impregnating metal oxide nanoparticles inside a polymer support, with or without functional groups, a hybrid nanosorbent material (HNM) can be prepared. A HNM is durable, mechanically strong, and chemically stable. The functional groups of the polymeric support will affect the overall removal efficiency of the ligands exerted by the Donnan Membrane Effect. For example, the removal of arsenic by HFO or the removal of fluoride by HZrO is enhanced by using anion exchange resins. The HNM can be precisely tuned to remove one type of contaminant over another type. Also, the physical morphology of the support material, spherical bead versus ion exchange fiber, has a significant effect on kinetics of sorption and desorption. HNMs also possess dual sorption sites and are capable of removing multiple contaminants, namely, arsenate and perchlorate, concurrently.

关键词： ion exchange     sorption     arsenic     perchlorate     fluoride    

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Multi-UAV cooperative target tracking with bounded noise for connectivity preservation

Rui Zhou, Yu Feng, Bin Di, Jiang Zhao, Yan Hu,jzhao@buaa.edu.cn

《信息与电子工程前沿（英文）》 2020年 第21卷 第10期   页码 1413-1534 doi: 10.1631/FITEE.1900617

摘要： We investigate cooperative target tracking of multiple unmanned aerial vehicles (UAVs) with a limited communication range. This is an integration of UAV motion control, target state estimation, and network topology control. We first present the communication topology and basic notations for , and introduce the distributed . Then, convergence and boundedness of the estimation errors using the filter are analyzed, and potential functions are proposed for communication link maintenance and collision avoidance. By taking stable target tracking into account, a distributed potential function based UAV motion controller is discussed. Since only the estimation of the target state rather than the state itself is available for UAV motion control and UAV motion can also affect the accuracy of state estimation, it is clear that the UAV motion control and target state estimation are coupled. Finally, the stability and convergence properties of the coupled system under are analyzed in detail and demonstrated by simulations.
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Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

null

《医学前沿（英文）》 2012年 第6卷 第1期   页码 35-40 doi: 10.1007/s11684-012-0171-0

摘要：

Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through “the cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor (α7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.

关键词： α7 nicotinic acetylcholine receptor     cardiovascular diseases     baroreflex sensitivity    

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标题 作者 时间 类型 操作

Multi-target combinatory strategy to overcome tumor immune escape

期刊论文

Atypical pituitary hormone–target tissue axis

期刊论文

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

null

期刊论文

Amodified variable rate particle filter for maneuvering target tracking

Yun-fei GUO,Kong-shuai FAN,Dong-liang PENG,Ji-an LUO,Han SHENTU

期刊论文

Lightweight design of an electric bus body structure with analytical target cascading

期刊论文

Dynamic Target Tracking of Unmanned Aerial Vehicles Under Unpredictable Disturbances

Yanjie Chen,Yangning Wu,Limin Lan,Hang Zhong,Zhiqiang Miao,Hui Zhang,Yaonan Wang,

期刊论文

A methodology of implementing target mixing ratio for asphalt mixture

Yucheng HUANG, Lun JI, Rui WEN, Ming ZHANG

期刊论文

应用基本遗传算法进行水面舰船目标识别研究

蒋定定,许兆林,李开端

期刊论文

Moving target detection in the cepstrum domain for passive coherent location (PCL) radar

Ji-chuan LI,Xiao-de LU,Hui ZHANG,Peng-cheng YANG,Yu LIU,Mao-sheng XIANG

期刊论文

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

期刊论文

Anovel approach of noise statistics estimate using H∞ filter in target tracking

Xie WANG,Mei-qin LIU,Zhen FAN,Sen-lin ZHANG

期刊论文

Speciation evolutions of target metals (Cd, Pb) influenced by chlorine and sulfur during sewage sludge

Jingde LUAN,Rundong LI,Zhihui ZHANG,Yanlong LI,Yun ZHAO

期刊论文

support and metal oxide nanoparticles in hybrid nanosorbent materials (HNMs) for sorption/desorption of target

Ryan C. SMITH,Jinze LI,Surapol PADUNGTHON,Arup K. SENGUPTA

期刊论文

Multi-UAV cooperative target tracking with bounded noise for connectivity preservation

Rui Zhou, Yu Feng, Bin Di, Jiang Zhao, Yan Hu,jzhao@buaa.edu.cn

期刊论文

Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

null

期刊论文